Gustavo Maegawa, M.D., Ph.D.

Gustavo Maegawa, M.D., Ph.D.

Title

Associate Professor of Pediatrics and Neuroscience

Contact Dr. Maegawa

Education

  • M.D. from Universidade Federal do Parana Medical School, Curitiba, Brazil
  • Ph.D from University of Toronto, Toronto, ON, Canada

Postdoctoral Training

  • Resident in Pediatrics and Medical Genetics, Hospital de Clinicas de Porto Alegre, Proto Alegre, Brazil
  • Fellow in Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON, Canada
  • Fellow in Clinical and Biochemical Research, The Hospital for Sick Children, Toronto, ON, Canada

Clinical Interests

  • Lysosomal storage diseases (LSDs)

Key Publications

  1. Maegawa GHB, Tropak M, Buttner JD, Rigat B, Fuller M, Pandit D, Tang L, Kornhaber GJ, Hamuro Y, Clarke JTR, Mahuran DJ. Identification and characterization of ambroxol as an enzyme-enhancement agent for Gaucher disease. J Biol Chem 2009 Aug 28;284(35):23502-16.
  2. Maegawa GHB, Banwell B, Blaser S, Hawkins C, Arckerley C, Hayes J, Tlopak M, Sorge G, Clarke Substrate reduction therapy in juvenile GM2 gangliosidosis. Mol Genet Metab. 2009 Sep-Oct;98(1-2):215-24
  3. Maegawa GHB, Giersbergen PV, Yang S, Banwell B, Morgan CP, Tifft C, Clarke Pharmacokinetics, tolerability and safety of miglustat as treatment of GM2 gangliosidosis. Mol Genet Metab 2009 Aug;97(4):284-91.
  4. Tropak, MB, Kornhaber, GJ, Rigat,BA, Maegawa GHB, Buttner J, Blanchard JE, Murphy C, Tuske SJ, Coales SJ, Hamuro Y, Brown E, Mahuran DJ. Identification of pharmacological chaperones for Gaucher disease nd characterization of their effects on b-glucocerebrosidase by hydrogen/deuterium exchange mass spectrometry. ChemBioChem 2008 (9), 2650-2662.
  5. Kornhaber GJ, Tropak MB, Maegawa GHB, Tuske SJ, Coales SJ, Mahuran DJ, Hamuro Y. Isofagomine Induced Stabilization of Glucocerebrosidaseā€ ChemBioChem 2008 (9), 2643-2649.

Honors & Awards

  • 2017 Shanghai Summit Forum on Pediatric Endocrine & Genetic Metabolic Diseases Appreciation Award
  • 2016 The Mathew Forbes Romer Foundation, Honoree for Contributions to LSDs

Current Research

Dr. Maegawa has a strong clinical interest in lysosomal storage diseases. He is the Principal Investigator of a lab dedicated to researching these disorders. To learn more about projects and specific research interests, please click the button below